Note: In 10.7 & 10.8, there is a bug with Spotlight which causes comments to work unreliably. This bug has been reported to Apple, but unsetting & resetting the Spotlight Comment usually helps OS X acknowledge the comment. You can also create a simple workflow connecting a keyword to a file.
If you want to tag applications with Spotlight Comments so that you can search for the app with your own keyword, go to Finder -> Get Info for the Application.
- In Finder, select the app you want to create the shortcut for and Get Info (cmd+i)
- Type your Spotlight Comment in the text box at the very top to set your shortcut.
Spotlight Comments for System-owned applications

If, when you try to type, you can't enter any text, follow the steps below:
- As above, select the app you want to create the shortcut for and Get Info (cmd+i)
- Check if the padlock at the bottom is unlocked: If it's locked, temporarily change the Sharing & Permissions setting for "everyone" to "Read & Write" and type your password in.
- Type your Spotlight Comment in the text box at the very top to set your shortcut.
IMPORTANT: Change the Sharing & Permissions setting for "everyone" back to "Read only" and relock the padlock.
Only applications owned by the System will require the padlock to be unlocked in order to set a Spotlight Comment. You can change this shortcut at any time by re-opening the Info window for your application.
Tip: You can tag Applications with more than one term, so you could for example tag all browsers with the 'browser' keyword. When typing browser in Alfred, you will then see all of your browsers.
You may have found this answer by using one of these keywords:

